[201][202], Pfizer indicated in its 9 November press release that 50 million doses could be available by the end of 2020, with about 1.3 billion doses provided globally by 2021. [182], The third stage is being conducted at Pfizer plants in Portage, Michigan[184] (near Kalamazoo) in the United States, and Puurs in Belgium. [213], BioNTech and Fosun agreed to supply Mainland China with a batch of 100 million doses in 2021, subject to regulatory approval. It is an RNA vaccine made of nucleoside-modified mRNA which is meant to create spike protein of SARS-CoV-2. [164][165], On 16 February 2021, the South African Health Products Regulatory Authority (SAHPRA) in South Africa issues Section 21, Emergency Use Approval for the vaccine. Pfizer Inc. engages in the discovery, development, and manufacture of healthcare products specializes in medicines, vaccine, and consumer healthcare. In 1880 there were 11 Pfizer families living in New York. : Pfizer, the world's largest research-based pharmaceutical company. [174], The adverse effect profile of the Pfizer–BioNTech COVID‑19 vaccine is similar to that of other adult vaccines. Die Firmenzentrale wurde 2008 von Karlsruhe nach Berlin verlegt. [67][191][192][189] In the United States, vials will be counted as five doses when accompanied by regular syringes and as six doses when accompanied by low dead space syringes. mit Sitz in Wien umfasst rezeptpflichtige Medikamente und rezeptfreie Produkte und zählt circa 250 Mitarbeiter. Pfizer(/ˈfaɪzər/)[3] is an American pharmaceutical corporation. From Simple English Wikipedia, the free encyclopedia, "Financial Review - Pfizer Inc. and Subsidiary Companies", "Pfizer moves higher amid persistent breakup talk", "Fortune 500 Companies 2018: Who Made the List", https://simple.wikipedia.org/w/index.php?title=Pfizer&oldid=7381345, Companies listed on the New York Stock Exchange, Pages with non-numeric formatnum arguments, Wikipedia articles with WorldCat identifiers, Creative Commons Attribution/Share-Alike License. The Pfizer–BioNTech COVID‑19 vaccine (pINN: tozinameran), sold under the brand name Comirnaty, is an mRNA based COVID-19 vaccine. [3] Sua sede de pesquisa e desenvolvimento encontra-se em Groton, Connecticut, e é uma das maiores empresas farmacêuticas do mundo. 70% had been to people aged 80 or over. It is ranked the largest drug company in the world. One of the world's largest pharmaceutical companies, it is ranked 64 on the 2020 Fortune 500 list of the largest United States corporations by total revenue. [18][204][205][206] By mid-December 2020, Pfizer had agreements to supply 300 million doses to the European Union,[207] 120 million doses to Japan,[208] 40 million doses (10 million before 2021) to the United Kingdom,[58] 20 million doses to Canada,[209] an unspecified number of doses to Singapore,[210] and 34.4 million doses to Mexico. [1][2] According to BioNTech, the name Comirnaty "represents a combination of the terms COVID‑19, mRNA, community, and immunity. Pfizer, la compagnie pharmaceutique mondialement reconnue. [134], On 8 December 2020, Margaret "Maggie" Keenan, 90, from Fermanagh, became the first person to receive the vaccine. New York had the highest population of Pfizer families in 1880. The Phase III results indicating a 95% effectiveness of the developed vaccine were published on 18 November 2020. [180] Once the mRNA has been created and purified, it is frozen in plastic bags about the size of a large shopping bag, of which each can hold up to 5 to 10 million doses. [28] In a report published on 4 March 2021 it concluded that "the benefits of Comirnaty in preventing COVID-19 continue to outweigh any risks, and there are no recommended changes regarding the use of this vaccine. [67], Severe allergic reaction has been observed in approximately 11 cases per million doses of vaccine administered. When used before surgery, it reduces pain but results in greater sedation and visual disturbances. [19] The vaccination requires two doses given three weeks apart. [187] Once fully operational, the facility would produce up to 750 million doses per year, or over 60 million doses per month. [59] The study will evaluate 30 µg of BNT162b2 or placebo administered via intramuscular injection in 2 doses, 21 days apart. This was 100% of all the recorded Pfizer's in the USA. The Phase II portion of the study will include approximately 350 pregnant women randomized 1:1 to receive BNT162b2 or placebo at 27 to 34 weeks' gestation. It was the vision of Charles Pfizer at the very beginning and it holds true today in everything we do. [55] The EMA clarified that the second dose should be administered three weeks after the first dose. The company is responsible for the first COVID-19 vaccination. Yrityksen pääkonttori sijaitsee New Yorkissa.Yrityksellä oli noin 90 000 työntekijää vuonna 2018, ja liikevaihdoltaan se on Fortune 500-listan mukaan maailman 61:nneksi suurin yritys. [161][162][163] The United States Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) approved recommendations for vaccination of those aged 16 years or older. [180] Therefore, all doses administered in the Americas outside of the United States have required at least two transatlantic flights (one to take DNA to Europe and one to bring back finished vaccine vials). At Pfizer, we apply science and our global resources to improve health and well-being at every stage of life. [60], The BioNTech technology for the BNT162b2 vaccine is based on use of nucleoside-modified mRNA (modRNA) which encodes part of the spike protein found on the surface of the SARS-CoV-2 coronavirus (COVID‑19), triggering an immune response against infection by the virus protein. We found 3 dictionaries with English definitions that include the word pfizer: Click on the first link on a line below to go directly to a page where "pfizer" is defined. [180], In February 2021, Pfizer revealed that the entire sequence initially took about 110 days on average from start to finish, and that the company was making progress on reducing that number to 60 days. [193], The vaccine needs to be stored at temperatures between −80 and −60 °C (−112 and −76 °F),[40] until five days before vaccination[39][40] when it can be stored at 2 to 8 °C (36 to 46 °F), and up to two hours at temperatures up to 25 °C (77 °F)[194][12] or 30 °C (86 °F). 辉瑞公司（英語： Pfizer, Inc. ， / ˈ f aɪ z ər / ），是一家总部位于美国 纽约的跨国制药、生物技術公司，研发总部位于康涅狄格州的格罗顿市。 根据收入排名，辉瑞是全球最大的制药公司。 輝瑞公司的股票於2004年4月8日成為道瓊斯工業指數的成份股。 [163][188] The use of low dead space syringes to obtain the additional doses is preferable, and partial doses within a vial should be discarded. "[219][220], The vaccine also has the common name "COVID‑19 mRNA vaccine (nucleoside-modified)"[2] and may be distributed in packaging with the name Pfizer–BioNTech COVID‑19 Vaccine. [22] During clinical trials, the side effects deemed very common[a] are (in order of frequency): pain and swelling at the injection site, tiredness, headache, muscle aches, chills, joint pain, and fever. [203], In July 2020, the vaccine development program Operation Warp Speed placed an advance order of US$1.95 billion with Pfizer to manufacture 100 million doses of a COVID‑19 vaccine for use in the United States if the vaccine was shown to be safe and effective. Pfizer Inc.: Working together for a healthier world® At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. The Phase III portion of this study will assess the safety, tolerability, and immunogenicity of BNT162b2 or placebo among pregnant women enrolled at 24 to 34 weeks' gestation. Clinical trials began in April 2020; by November the vaccine entered phase III clinical trials, based on more than 40,000 people. [63] It consists of a five-prime cap; a five prime untranslated region derived from the sequence of human alpha globin; a signal peptide (bases 55–102) and two proline substitutions (K986P and V987P, designated "2P") that cause the spike to adopt a prefusion-stabilized conformation reducing the membrane fusion ability, increasing expression and stimulating neutralizing antibodies;[19][64] a codon-optimized gene of the full-length spike protein of SARS-CoV-2 (bases 103–3879); followed by a three prime untranslated region (bases 3880–4174) combined from AES and mtRNR1 selected for increased protein expression and mRNA stability[65] and a poly(A) tail comprising 30 adenosine residues, a 10-nucleotide linker sequence, and 70 other adenosine residues (bases 4175–4284). [63] The 2P proline substitutions in the spike proteins were originally developed for a MERS vaccine by researchers at the National Institute of Allergy and Infectious Diseases’ Vaccine Research Center, Scripps Research, and Jason McLellan’s team (currently at the University of Texas at Austin, previously at Dartmouth College). Licensing . The site will be the third BioNTech facility in Europe which currently produces the vaccine, while Pfizer operates at least four production sites in the United States and Europe. [67] Fever is more common after the second dose. Both doses should be Pfizer-BioNTech COVID-19 Vaccine. ALC-0159 is a polyethylene glycol conjugate (that is, a PEGylated lipid). The company bought Wyeth, which also used to be a drug company. There, they produced an antiparasitic called santonin. [21][22] The most common side effects include mild to moderate pain at the injection site, fatigue, and headache. [182] At this stage, it takes only four days to go from mRNA and lipids to finished vials, but each lot must then spend several weeks in deep-freeze storage while undergoing verification against 40 quality-control measures. [20] For approval in the EU, an overall vaccine efficacy of 95% was confirmed by the EMA. The DNA is stored in tiny bottles and frozen for shipment. Am Produktionsstandort in Orth/Donau sind rund 230 Mitarbeiter in der Pfizer Manufacturin… [23], Preliminary results from Phase I–II clinical trials on BNT162b2, published in October 2020, indicated potential for its efficacy and safety. The first stage involves the molecular cloning of DNA plasmids that code for the spike protein by infusing them into Escherichia coli bacteria. It became the first COVID-19 vaccine to receive definitive registration rather than emergency use authorization in the country. Erhart died in 1891, and Pfizer in 1906, leaving a company of around 200 employees in the hands of Emil Pfizer, who served as president until the 1940s, the last member of the Pfizer … [2] Företaget har 80 000 medarbetare och finns i fler än 150 länder. At Pfizer, we innovate every day to make the world a healthier place. After four days of growth, the bacteria are killed and broken open, and the contents of their cells are purified over a week and a half to recover the desired DNA product. Argentina - Español Australia - English Austria - Deutsch. [20] The early-stage research determined the safety and dose level for two vaccine candidates, with the trial expanding during mid-2020 to assess efficacy and safety of BNT162b2 in greater numbers of participants, reaching tens of thousands of people receiving test vaccinations in multiple countries in collaboration with Pfizer and Fosun. [40], Before COVID-19 vaccines, a vaccine for an infectious disease had never before been produced in less than several years, and no vaccine existed for preventing a coronavirus infection in humans. [2][171][172] The recommendation was accepted by the European Commission the same day. Size of this PNG preview of this SVG file: 800 × 479 pixels. The company is partnered on this project with Pfizer and Fosun.. General (2 matching dictionaries) Pfizer, pfizer: Wordnik [home, info] Pfizer: Wikipedia, the Free Encyclopedia [home, info] Slang (1 … [27][28] Monitoring of the primary outcomes from the trials will continue until August 2021, while monitoring of the secondary outcomes will continue until January 2023. [4 História. It was founded in 1849 in New York City. For other vaccination topics, see, A vial of the Pfizer–BioNTech COVID‑19 vaccine, US authorization also includes the three sovereign nations in the, Chinese Center for Disease Control and Prevention, COVID-19 vaccine § Clinical trials started in 2020, National Institute of Allergy and Infectious Diseases, 1,2-distearoyl-sn-glycero-3-phosphocholine, Medicines and Healthcare products Regulatory Agency, Centers for Disease Control and Prevention, Advisory Committee on Immunization Practices, Swiss Agency for Therapeutic Products (Swissmedic), Committee for Medicinal Products for Human Use, "Swissmedic grants authorisation for the first COVID-19 vaccine in Switzerland", "Comirnaty (BNT162b2 [mRNA]) COVID‑19 Vaccine Product Information", Australian Public Assessment Report for BNT162b2 (mRNA), "Regulatory Decision Summary – Pfizer-BioNTech COVID-19 Vaccine", "Pfizer-BioNTech COVID-19 Vaccine (tozinameran)", "Information for Healthcare Professionals on Pfizer/BioNTech COVID-19 vaccine", "Conditions of Authorisation for Pfizer/BioNTech COVID-19 vaccine", "FDA Takes Key Action in Fight Against COVID-19 By Issuing Emergency Use Authorization for First COVID-19 Vaccine", "Pfizer-BioNTech COVID-19 Vaccine- rna ingredient bnt-162b2 injection, suspension", Pfizer-BioNTech COVID-19 Vaccine Emergency Use Authorization Review Memorandum, "Pfizer-BioNTech COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 16 Years of Age and Older", "mRNA vaccines to address the COVID-19 pandemic", "What you need to know about BioNTech – the European company behind Pfizer's Covid-19 vaccine", "Pfizer's early data shows vaccine is more than 90% effective", "Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates", "Pfizer says experimental COVID-19 vaccine is more than 90% effective", "Covid-19 vaccine from Pfizer and BioNTech is strongly effective, early data from large trial indicate", "Update on our COVID-19 vaccine development program with BNT162b2", "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "Questions and Answers About Pfizer-BioNTech COVID-19 Vaccine", "UK medicines regulator gives approval for first UK COVID-19 vaccine", "UK approves Pfizer/BioNTech Covid vaccine for rollout next week", "EMA recommends first COVID-19 vaccine for authorisation in the EU", "Bahrain becomes second country to approve Pfizer COVID-19 vaccine", "Coronavirus: Saudi Arabia approves Pfizer COVID-19 vaccine for use", "Mexico approves emergency use of Pfizer's COVID-19 vaccine", "F.D.A.
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