You should not use sodium polystyrene sulfonate if you have low potassium levels or a bowel obstruction. Dispense in tight, light-resistant containers as defined in the official compendia. The majority of these cases reported the concomitant use of sorbitol. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. KAYEXALATE, brand of sodium polystyrene sulfonate is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula: The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an . Avoid using antacids or laxatives without your doctor's advice. Sodium Polystyrene Sulfonate Suspension USP (SPS® Suspension) can be administered orally or in an enema. Store at 25° C (77° F); excursions permitted to 15° – 30° C (59° – 86° F) [see USP Controlled Room Temperature]. Exchange Resin (About this - PubMed Health) Uses Uses of This Medicine SODIUM POLYSTYRENE SULFONATE (SOE dee um pol ee STYE reen SUHL fuh neyt) takes potassium out of the body by binding to it in the intestines. Sodium Polystyrene Sulfonate is a potassium ion exchange resin composed of benzene -diethyl polymer with ethenyl-benzene, sulfonated, sodium salt. This action occurs primarily in the large intestine, which excretes potassium ions to a greater degree than does the small intestine. 70,000 . Generic Name: sodium polystyrene sulfonate (SOE dee um pol ee STEER een SUL foe nate)Brand Name: Kalexate, Kayexalate, KionexDosage Forms: oral and rectal powder (-); oral and rectal suspension (15 g/60 mL). Medically reviewed by Drugs.com. One gram of Sodium Polystyrene Sulfonate contains 4.1 mEq of sodium. Limitation of Use: Sodium Polystyrene Sulfonate should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action [see Clinical Pharmacology (12.2)]. You should not use sodium polystyrene sulfonate if you are allergic to it, or if you have: a weak immune system caused using certain medicine; severe constipation or other bowel problems; kidney disease (or if you are on dialysis); an electrolyte imbalance (such as low levels of potassium, calcium, or magnesium in your blood); a bowel disorder, or surgery on your intestines; Because sodium polystyrene sulfonate is not absorbed into the bloodstream, this medicine is not expected to be harmful during pregnancy or while nursing a baby. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The amount of medicine that you take depends on the strength of the medicine. The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an exchange capacity of approximately 3.1 mEq (approximately 1 mEq) of potassium per gram. A client has a prescription to take sodium polystyrene sulfonate for several days. ECI Pharmaceuticals, LLC Fort Lauderdale, FL 33309. This medicine is available only with your doctor's prescription. Cabbage Mushrooms Strawberries. The average total daily adult dose of Sodium Polystyrene Sulfonate is 15 g to 60 g, administered as a 15-g dose (four level teaspoons), one to four times daily. Sodium polystyrene sulfonate may also be used for purposes not listed in this medication guide. Store at room temperature away from moisture and heat. Do not use potassium supplements, calcium supplements, or salt substitutes while you are taking sodium polystyrene sulfonate, unless your doctor has told you to. You may report side effects to FDA at 1-800-FDA-1088. This medication is used to treat a high level of potassium in your blood. Quasi-elastic light-scattering spectroscopy was used to measure the diffusion coefficient of polystyrene latex spheres of diameters 14, 67, and 189 nm in relatively dilute (concentrations 0 ≤ c ≤ 20 g/L) solutions of polystyrene sulfonate. Polymer molecular weights were in the range 1.5 ≤ M ≤ 1188 kDa; solvents were in the high-salt (0.2M NaCl) regime. Sodium polystyrene sulfonate works differently from other medicines because it passes into your intestines without being absorbed into your blood stream. Sodium Polystyrene Sulfonate is a non-absorbed, cation exchange polymer that contains a sodium counterion. Monitor calcium and magnesium in patients receiving Sodium Polystyrene Sulfonate. Use the HNE Drug Lookup to find the prescription drugs that we consider medically appropriate and cost effective to keep health care affordable for everyone.. Is your drug covered? Stop using sodium polystyrene sulfonate and call your doctor at once if you have: severe constipation, severe stomach pain, bloating; confusion, thinking problems, feeling irritable; low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; low calcium levels--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or. Written by Cerner Multum. Follow all directions on your prescription label and read all medication guides or instruction sheets. Sodium polystyrene sulfonate for suspension is available as a golden brown, finely ground powder in jars of 1 pound (454 g), NDC 11534-166-44, in bottles of 15 g, NDC 11534-166-16 and 10 in 1... 17 PATIENT COUNSELING INFORMATION Average adult dose: 15 g (approximately 4 level Teaspoons) one to four times daily in water. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. Premature infants or low birth weight infants may have an increased risk for gastrointestinal adverse effects with Sodium Polystyrene Sulfonate use [see Warnings and Precautions (5.4)]. Sodium Polystyrene Sulfonate is not absorbed systemically following oral or rectal administration and maternal use is not expected to result in fetal risk. If your dose is different, do not change it unless your doctor tells you to do so. Avoid taking other medicines within 3 hours before or 3 hours after you take sodium polystyrene sulfonate. The effect must be carefully controlled by frequent serum potassium determinations within each 24 hour period. The sodium content is approximately 4.1 mmol Synonyms SDS Certificate of Analysis Product Specification Technical Inquiry Stock No. The practical exchange ratio is 1 mEq K per 1 gram of resin. Advise patients who are taking other oral medication to separate the dosing of Sodium Polystyrene Sulfonate by at least 3 hours (before or after) [see Dosage and Administration (2.1), Warnings and Precautions (5.5), and Drug Interactions (7.1)]. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Hypersensitivity to polystyrene sulfonate resins, The drug is a cream to light brown finely ground, powdered form of Sodium Polystyrene Sulfonate, a cation-exchange resin prepared in the sodium phase with an, Store at 25° C (77° F); excursions permitted to 15° – 30° C (59° – 86° F), Sodium Polystyrene Sulfonate powder, for suspension, We comply with the HONcode standard for trustworthy health information -. Drug classes. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. Concomitant administration of sorbitol is not recommended. Sodium content approximately 60 mEq per 15 g. Suspension should be freshly prepared and not stored beyond 24 hours. Monitor serum potassium during therapy because severe hypokalemia may occur. SODIUM POLYSTYRENE SULFONATE takes potassium out of the body by binding to it in the intestines. Select all that apply. Administer with patient in an upright position [see Warnings and Precautions (5.4)]. Sodium polystyrene sulfonate removes potassium by exchanging sodium ions for potassium ions in the intestine. Do not give sodium polystyrene sulfonate orally (by mouth) to a newborn baby. Sodium polystyrene sulfonate is in a class of medications called potassium-removing agents. Sodium Polystyrene Sulfonate (By mouth) SOE-dee-um pol-ee-STYE-reen SUL-foe-nate. Generic Name: Sodium Polystyrene Sulfonate Powder (SOE dee um POL ee STYE reen SUL foe nate) Brand Name: Kayexalate, Kionex. Avoid eating or drinking anything that contains sorbitol (a fruit sugar often used as a sweetener in chewing gum, diet drinks, baked goods, or frozen desserts). If necessary, sodium polystyrene sulfonate may be administered into the stomach through a plastic tube. Binding of Sodium Polystyrene Sulfonate to other oral medications could cause decreased gastrointestinal absorption and loss of efficacy when taken close to the time Sodium Polystyrene Sulfonate is administered. Use only in patients who have normal bowel function. Do not give this medicine orally (by mouth) to a newborn baby. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Binding of potassium reduces the concentration of free potassium in the gastrointestinal lumen, resulting in a reduction of serum potassium levels. The lowest GoodRx price for the most common version of generic Kayexalate is around $21.29, 38% off the average retail price of $34.84. Other drugs may affect sodium polystyrene sulfonate, including prescription and over-the-counter medicines, vitamins, and herbal products. Copyright 1996-2021 Cerner Multum, Inc. For non-prescription products, read the label or package ingredients carefully. It is used to treat too much potassium in the body. The average adult dose is 30 g to 50 g every six hours. Version: 4.02. sodium bicarbonate, Kayexalate, insulin regular, calcium gluconate, Humulin R, Veltassa. We comply with the HONcode standard for trustworthy health information -, Sodium polystyrene sulfonate side effects, Detailed Sodium polystyrene sulfonate dosage information, Sodium polystyrene sulfonate drug interactions. Administer Sodium Polystyrene Sulfonate at least 3 hours before or 3 hours after other oral medications. signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. The simultaneous oral administration of Sodium Polystyrene Sulfonate with nonabsorbable cation- donating antacids and laxatives may reduce the resin's potassium exchange capability and increase the risk of systemic alkalosis. The latest research on Global Sodium Polystyrene Sulfonate Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 comprises a fully comprehensive assessment of the industry vertical and highlights the various market segmentation. The efficiency of this process is limited and unpredictably variable. KAYEXALATE (sodium polystyrene sulfonate) is a cream or light brown fine powder of sodium polystyrene sulfonate. Sodium Polystyrene Sulfonate is indicated for the treatment of hyperkalemia. Sodium Polystyrene Sulfonate increases fecal potassium excretion through binding of potassium in the lumen of the gastrointestinal tract. Sodium polystyrene sulfonate is a cream to light brown, finely ground powder and is available in 453.6 g jars. The client also needs to make some dietary changes. This medication is used to treat a high level of potassium in your blood. Sodium polystyrene sulfonate can be given as a liquid by mouth, through a stomach feeding tube, or as a rectal enema. Applies to sodium polystyrene sulfonate: oral or rectal powder for suspension, oral or rectal suspension Side effects include: Gastric irritation, anorexia, constipation, diarrhea, fecal impaction, GI concretions (bezoars), nausea, vomiting, hypokalemia, hypocalcemia, hypomagnesemia, clinically important sodium retention. Follow your doctor's orders or the directions on the label. In some The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram.The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. After an initial cleansing enema, insert a soft, large size (French 28) rubber tube into the rectum for a distance of about 20 cm, with the tip well into the sigmoid colon, and tape in place. Administer Sodium Polystyrene Sulfonate with the patient in an upright position. Last updated on Dec 1, 2019. Prepare suspension fresh and use within 24 hours. [see Dosage and Administration (2.1) and Drug Interactions (7)]. Ensure an adequate volume of cleansing solution (up to 2 liters) is utilized. You will need frequent medical tests to help your doctor determine how long to treat you with sodium polystyrene sulfonate. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Select one or more newsletters to continue. Store at 25° C (77° F); excursions permitted to 15 to 30° C (59 to 86° F) [see USP Controlled Room Temperature], Distributed by Alexso, Inc. Los Angeles, CA 90064, sodium bicarbonate, Kayexalate, insulin regular, calcium gluconate, Humulin R, Veltassa. Risk factors for gastrointestinal adverse events were present in many of the cases including prematurity, history of intestinal disease or surgery, hypovolemia, and renal insufficiency and failure. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. Hemodialysis or hemofiltration. Sodium Polystyrene Sulfonate is indicated for the treatment of hyperkalemia. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 41688 Poly(styrene sulfonic acid) sodium salt, M.W. In pediatric patients, as in adults, Sodium Polystyrene Sulfonate is expected to bind potassium at the practical exchange ratio of 1mEq potassium per 1 gram of resin. KAYEXALATE is a cation-exchange resin prepared in the sodium phase, with an in vivo exchange capacity of approximately 1 mmol (in vitro approximately 3.1 mmol) of potassium per gram. Adjustment of other sources of sodium may be required. This medicine may be used for other purposes; ask your health care provider or … The following adverse reactions are discussed elsewhere in the labeling: The following adverse reactions have been identified during post-approval use of Sodium Polystyrene Sulfonate. Some may affect sodium polystyrene sulfonate, especially: drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection. Patients with gastroparesis may require a 6 hour separation. Sodium Polystyrene Sulfonate is available as a cream to light brown, finely ground powder in jars of 1 pound (453.6 g), NDC 50488-5001-1. A somewhat thicker suspension may be used, but do not form a paste. 16 Hypokalemia is rarely suspected on the basis of clinical presentation; the diagnosis is made by meas-urement of serum potassium. To give this medicine orally: Mix the sodium polystyrene sulfonate powder with water, or with honey or jam to make it taste better. Sodium Polystyrene Sulfonate is not absorbed systemically by the mother, so breastfeeding is not expected to result in risk to the infant. Polystyrene sulfonates are a group of medications used to treat high blood potassium. The effective lowering of serum potassium with Sodium Polystyrene Sulfonate may take hours to days. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Suspend each dose in a small quantity of water or syrup, approximately 3 to 4 mL of liquid per gram of resin. Sodium Polystyrene Sulfonate has the potential to bind other drugs. Effects generally take hours to days. Sodium Polystyrene Sulfonate is not absorbed systemically. sodium polystyrene sulfonate) Administration of IV Insulin-Glucose, and inhaled beta-agonists (albuterol) IV Calcium administration to prevent cardiac arrythmias. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. In both children and neonates, excessive dosage or inadequate dilution could result in impaction of the resin. The report evaluates the opportunities and current market scenario, providing insights and updates about the … Avoid inhaling the oral powder while you are preparing a dose. Patients with gastroparesis may require a 6 hour separation. Medically reviewed by Drugs.com on April 4, 2019. The in vivo efficiency of sodium-potassium exchange resins is approximately 33 percent; hence, about one third of the resin's actual sodium content is delivered to the body. Monitor patients who are sensitive to sodium intake (heart failure, hypertension, edema) for signs of fluid overload. Avoid use in patients who are at risk for developing constipation or impaction (including those with history of impaction, chronic constipation, inflammatory bowel disease, ischemic colitis, vascular intestinal atherosclerosis, previous bowel resection, or bowel obstruction). Studies of safety and efficacy have not been conducted in pediatric patients. Tell your doctor if you are pregnant or breast-feeding. Sodium polystyrene sulfonate is used to treat hyperkalemia (increased amounts of potassium in the body). As the resin passes along the intestine or is retained in the colon after administration by enema, the sodium ions are partially released and are replaced by potassium ions. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or establish a causal relationship to drug exposure. Too much potassium in your blood can sometimes cause heart rhythm problems. Sodium Polystyrene Sulfonate is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula: The drug is a cream to light brown finely ground, powdered form of Sodium Polystyrene Sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram.
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